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Reduction in blood fibrinogen level decreases the coagulability of the blood. Since fibrinogen (MW ~340 000) contributes to the viscosity of blood, an improved “fluidity” of the blood would be expected. Both effects are felt to be of benefit in the treatment of certain disorders of blood flow.
Smaller dextran molecules can be filtered at the glomerulus and slowly excreted in urine; the larger ones are eventually taken up and degraded by cells of the reticuloendothelial system. Apart from restoring blood volume, dextran solutions are used for hemodilution in the management of blood flow disorders. |
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